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Aniline Catalysis in Bioconjugations and Material Synthesis
Cai Mao; Han Yanfang; Zhang Qi; Luo Sanzhong
JAN 25 2018
Source PublicationCHINESE JOURNAL OF ORGANIC CHEMISTRY
Volume38Issue:1Pages:1-10
AbstractThe oxime or hydrazone formation is a classic condensation reaction between aldehydes/ketones and hydroxyl amine or hydrazine. It is a simple, yet fundamental coupling reaction that has been widely applied in the ligations and conjugations of biomolecules and material synthesis. However, the reactions are usually sluggish and normally require acidic conditions with large excess of substrates to facilitate conversion, which limit their wide applications. Recent studies have shown that aniline as a nucleophilic catalyst can significantly accelerate the oxime/hydrazone formation reaction, preliminarily solving the reaction rate issue under mild and bio-compatible conditions. Therefore, it has been the most common coupling method in the modification of biological macromolecules. In this review, the design and development of aromatic amine catalyst in recent years as well as the catalytic mechanism and structure activity relationship are summarized. The application of highly active aniline catalysis in bioconjugations and material synthesis was also included together with a prospect for future development.
WOS IDWOS:000424748800001
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Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/38823
Collection其它
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GB/T 7714
Cai Mao,Han Yanfang,Zhang Qi,et al. Aniline Catalysis in Bioconjugations and Material Synthesis[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,JAN ,38(1):1-10.
APA Cai Mao,Han Yanfang,Zhang Qi,&Luo Sanzhong.(JAN ).Aniline Catalysis in Bioconjugations and Material Synthesis.CHINESE JOURNAL OF ORGANIC CHEMISTRY,38(1),1-10.
MLA Cai Mao,et al."Aniline Catalysis in Bioconjugations and Material Synthesis".CHINESE JOURNAL OF ORGANIC CHEMISTRY 38.1(JAN ):1-10.
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