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Charge-Induced Secondary Structure Transformation of Amyloid-Derived Dipeptide Assemblies from beta-Sheet to alpha-Helix
Xing, Ruirui; Yuan, Chengqian; Li, Shukun; Song, Jingwen; Li, Junbai; Yan, Xuehai
FEB 5 2018
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume57Issue:6Pages:1537-1542
AbstractSecondary structures such as alpha-helix and beta-sheet are the major structural motifs within the three-dimensional geometry of proteins. Therefore, structure transitions from beta-sheet to alpha-helix not only can serve as an effective strategy for the therapy of neurological diseases through the inhibition of -sheet aggregation but also extend the application of alpha-helix fibrils in biomedicine. Herein, we present a charge-induced secondary structure transition of amyloid-derived dipeptide assemblies from beta-sheet to alpha-helix. We unravel that the electrostatic (charge) repulsion between the C-terminal charges of the dipeptide molecules are responsible for the conversion of the secondary structure. This finding provides a new perspective to understanding the secondary structure formation and transformation in the supramolecular organization and life activity.
WOS IDWOS:000423494500017
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Cited Times:44[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/38798
Collection其它
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GB/T 7714
Xing, Ruirui,Yuan, Chengqian,Li, Shukun,et al. Charge-Induced Secondary Structure Transformation of Amyloid-Derived Dipeptide Assemblies from beta-Sheet to alpha-Helix[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,FEB ,57(6):1537-1542.
APA Xing, Ruirui,Yuan, Chengqian,Li, Shukun,Song, Jingwen,Li, Junbai,&Yan, Xuehai.(FEB ).Charge-Induced Secondary Structure Transformation of Amyloid-Derived Dipeptide Assemblies from beta-Sheet to alpha-Helix.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,57(6),1537-1542.
MLA Xing, Ruirui,et al."Charge-Induced Secondary Structure Transformation of Amyloid-Derived Dipeptide Assemblies from beta-Sheet to alpha-Helix".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 57.6(FEB ):1537-1542.
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