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Ultrasensitive and high specific detection of non-small-cell lung cancer cells in human serum and clinical pleural effusion by aptamer-based fluorescence spectroscopy
Wu, Yuhang; Zhang, Hong; Xiang, Junfeng; Mao, Zhihua; Shen, Gang; Yang, Fengmin; Liu, Yan; Wang, Wei; Du, Ning; Zhang, Jinghua; Tang, Yalin
MAR 1 2018
Source PublicationTALANTA
Volume179Pages:501-506
AbstractLung cancer is the leading cause of cancer-related deaths worldwide, and approximately 85% are diagnosed as non-small-cell lung cancer (NSCLC). However, efficient detection and diagnosis of NSCLC at early stage is still challenging. In this work, we developed a simple, ultrasensitive and high selective strategy for A549 human NSCLC cells detection based on combining the reorganization property of a novel cyanine dye 3,3'-di(3-sulfopropyl)-4,5,4',5'-dibenzo-9-methyl-thiacarbocyanine triethylammonium salt (cy-M) to aptamer S6 G-quadruplex structure having specific affinity to NSCLC cells, which induced a dramatic fluorescence enhancement (similar to 10(4) times). Moreover, this strategy was successfully used for detecting of A549 cancer cells in complex media such as human serum and clinical pleural effusion, which strong indicated that the proposed method could be applied for the early diagnosis of lung cancer.
WOS IDWOS:000424178000068
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Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/38743
Collection其它
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GB/T 7714
Wu, Yuhang,Zhang, Hong,Xiang, Junfeng,et al. Ultrasensitive and high specific detection of non-small-cell lung cancer cells in human serum and clinical pleural effusion by aptamer-based fluorescence spectroscopy[J]. TALANTA,MAR ,179:501-506.
APA Wu, Yuhang.,Zhang, Hong.,Xiang, Junfeng.,Mao, Zhihua.,Shen, Gang.,...&Tang, Yalin.(MAR ).Ultrasensitive and high specific detection of non-small-cell lung cancer cells in human serum and clinical pleural effusion by aptamer-based fluorescence spectroscopy.TALANTA,179,501-506.
MLA Wu, Yuhang,et al."Ultrasensitive and high specific detection of non-small-cell lung cancer cells in human serum and clinical pleural effusion by aptamer-based fluorescence spectroscopy".TALANTA 179(MAR ):501-506.
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