ICCAS OpenIR  > 分子纳米结构与纳米技术实验室
Amino acid functionalized gadofullerene nanoparticles with superior antitumor activity via destruction of tumor vasculature in vivo
Zhou, Yue1,2; Deng, Ruijun1,2; Zhen, Mingming1,2; Li, Jie1,2; Guan, Mirong1; Jia, Wang1,2; Li, Xue1,2; Zhang, Ying1,2; Yu, Tong1,2; Zou, Toujun1; Lu, Zhigao1,2; Guo, Jun1; Sun, Lei3; Shu, Chunying1,2; Wang, Chunru1,2
2017-07-01
Source PublicationBIOMATERIALS
Volume133Pages:107-118
AbstractResearchers have been puzzled of the therapy of malignant tumors and the current therapeutic strategies are always accompanied by toxicity or side effects. Developing efficient nanodrugs could reduce the dosage and greatly improve the therapeutic effects in cancer treatments. Here we initially reported a novel kind of gadofullerene nanoparticles functionalized with amino acid (beta-alanine), which exhibited a superior antitumor activity in hepatoma H22 models via a novel therapeutic mechanism. The involvement of beta-alanine improved the tumor inhibition rate up to 76.85% for a single treatment by strengthening the interaction with radiofrequency (RF) and extending blood circulation time. It realized a highly antivascular treatment to cut off the nutrient supply of tumor cells by physically destroying the abnormal tumor blood vessels assisted by RF. In situ and real-time observation of the vascular change was conducted using the dorsal skin fold chamber model, which corresponded to the erythrocyte diapedesis in histopathological examination. The ultrastructural changes of vascular endothelial cells were further investigated by environmental scanning electron microscopy and transmission electron microscopy. Long-term toxicity evaluation showed that the GF-Ala nanoparticles could be eliminated from the mice after several days and no obvious toxicity was found to the main organs. All these encouraging results suggest GF-Ala nanoparticles are valuable for the significant therapeutic potential with high-efficacy and low-toxicity. (C) 2017 Elsevier Ltd. All rights reserved.
KeywordGadofullerene Amino Acid Tumor Vascular Targeting Treatment Dorsal Skin Fold Chamber Radiofrequency
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/38402
Collection分子纳米结构与纳米技术实验室
Affiliation1.Chinese Acad Sci, CAS Res Educ Ctr Excellence Mol Sci, Key Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci,Inst Chem, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Inst Biophys, Ctr Biol Imaging, Beijing 100101, Peoples R China
Recommended Citation
GB/T 7714
Zhou, Yue,Deng, Ruijun,Zhen, Mingming,et al. Amino acid functionalized gadofullerene nanoparticles with superior antitumor activity via destruction of tumor vasculature in vivo[J]. BIOMATERIALS,2017,133:107-118.
APA Zhou, Yue.,Deng, Ruijun.,Zhen, Mingming.,Li, Jie.,Guan, Mirong.,...&Wang, Chunru.(2017).Amino acid functionalized gadofullerene nanoparticles with superior antitumor activity via destruction of tumor vasculature in vivo.BIOMATERIALS,133,107-118.
MLA Zhou, Yue,et al."Amino acid functionalized gadofullerene nanoparticles with superior antitumor activity via destruction of tumor vasculature in vivo".BIOMATERIALS 133(2017):107-118.
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