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题名: DNA-Based Nanopore Sensing
作者: Liu, Lei1; Wu, Hai-Chen1, 2
关键词: current signatures ; DNA probes ; nanopores ; quantification ; sensing
刊名: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
发表日期: 2016-12-05
卷: 55, 期:49, 页:15216-15222
收录类别: SCI
英文摘要: Nanopore sensing is an attractive, label-free approach that can measure single molecules. Although initially proposed for rapid and low-cost DNA sequencing, nanopore sensors have been successfully employed in the detection of a wide variety of substrates. Early successes were mostly achieved based on two main strategies by 1)creating sensing elements inside the nanopore through protein mutation and chemical modification or 2)using molecular adapters to enhance analyte recognition. Over the past fiveyears, DNA molecules started to be used as probes for sensing rather than substrates for sequencing. In this Minireview, we highlight the recent research efforts of nanopore sensing based on DNA-mediated characteristic current events. As nanopore sensing is becoming increasingly important in biochemical and biophysical studies, DNA-based sensing may find wider applications in investigating DNA-involving biological processes.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/36434
Appears in Collections:活体分析化学实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China
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