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题名: MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles
作者: Qiao, Hongyu1, 2; Wang, Yabin1; Zhang, Ruohan3; Gao, Quansheng6; Liang, Xiao4; Gao, Lei1; Jiang, Zhenhua2; Qiao, Ruirui5; Han, Dong2; Zhang, Yan1; Qiu, Ya1; Tian, Jie4; Gao, Mingyuan5; Cao, Feng1, 2
关键词: Dual-modality molecular imaging ; Atherosclerotic plaques ; Macrophages ; Nanoparticles
刊名: BIOMATERIALS
发表日期: 2017
卷: 112, 页:336-345
收录类别: SCI
英文摘要: Rupture of vulnerable atherosclerotic plaque is the major pathological cause of luminal thrombosis in acute coronary syndromes. Since foamy macrophages have been identified as a prominent component in vulnerable atherosclerotic lesions and osteopontin (OPN) is reported to be highly expressed in foamy macrophages, OPN could be a potential target for vulnerable atherosclerotic plaque imaging. The current study designed an OPN-specific MRI/optical dual-modality probe to detect vulnerable plaques. Fluorescence imaging revealed that 24 h after injection of the Cy5.5-OPN-DMSA-MNPs (COD-MNPs), the atherosclerotic plaques in carotid artery exhibited significant higher signals in high fat diet (HFD) fed mice in comparison to the group injected with Cy5.5-IgG-DMSA-MNPs (CID-MNPs) or normal diet fed group injected with COD-MNPs (1.87 +/- 0.19 x 10(10) vs. 0.74 +/- 0.04 x 10(10), 0.73 +/- 0.03 x 10(10) p/sec/cm(2)/sr, P < 0.05). Meanwhile, MRI displayed stronger T-2 contrast enhancement 24 h post-injection at the area of atherosclerotic plaques in the carotid of HFD fed group injected with COD-MNPs than group injected with CID-MNPs or normal diet fed group injected with COD-MNPs (post/pre signal ratio: 0.64 +/- 0.04 vs. 0.95 +/- 0.02, 0.98 +/- 0.01, P < 0.05). As a dual-modality molecular probe, the resulting COD-MNPs conjugates exhibit promising potentials for noninvasive detection of vulnerable atherosclerotic plaque in vivo. (C) 2016 Elsevier Ltd. All rights reserved.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/36433
Appears in Collections:胶体、界面与化学热力学实验室_期刊论文

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作者单位: 1.Chinese PM Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China
2.Dept Cardiol, Xijing Hosp, Dept Cardiol, Xian 710032, Peoples R China
3.Fourth Mil Med Univ, Xijing Hosp, Dept Hepatobiliary & Pancretosplen Surg, Xian 710032, Peoples R China
4.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China
5.Chinese Acad Sci, Inst Chem, Bei Yi Jie 2, Beijing 100190, Peoples R China
6.Acad Mil Med Sci, Lab Anim Ctr, Beijing 100850, Peoples R China
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