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题名: Functionalized Nano-MoS2 with Peroxidase Catalytic and Near-Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications
作者: Yin, Wenyan1; Yu, Jie1, 2; Lv, Fengting3; Yan, Liang1; Zheng, Li Rong1; Gu, Zhanjun1; Zhao, Yuliang1, 4
关键词: MoS2 ; peroxidase-like activity ; wound disinfection ; photothermal therapy
刊名: ACS NANO
发表日期: 2016-12-01
卷: 10, 期:12, 页:11000-11011
收录类别: SCI
英文摘要: We have developed a biocompatible antibacterial system based on polyethylene glycol functionalized molybdenum disulfide nanoflowers (PEG-MoS2 NFs). The PEG-MoS2 NFs have high near-infrared (NIR) absorption and peroxidase-like activity, which can efficiently catalyze decomposition of low concentration of H2O2 to generate hydroxyl radicals (center dot OH). The conversion of H2O2 into center dot OH can avoid the toxicity of high concentration of H2O2 and the center dot OH has higher antibacterial activity, making resistant bacteria more vulnerable and wounds more easily cured. The PEG-MoS2 NFs combine the catalysis with MR photothermal effect, providing a rapid and effective killing outcome in vitro for Gram-negative ampicillin resistant Escherichia coli (Amp(r) E. coli) and Gram-positive endospore-forming Bacillus subtilis (B. subtilis) as compared to catalytic treatment or photothermal therapy (PTT) alone. Wound healing results indicate that the synergy antibacterial system could be conveniently used for wound disinfection in vivo. Interestingly, glutathione (GSH) oxidation can be accelerated due to the 808 mu irradiation induced hyperthermia at the presence of PEG-MoS2 NFs proved by X-ray near-edge absorption spectra and X-ray spectroscopy. The accelerated GSH oxidation can result in bacterial death more easily. A mechanism based on center dot OH-enhanced PTT is proposed to explain the antibacterial process.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/36333
Appears in Collections:有机固体实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China
2.Northwestern Polytech Univ, Key Lab Polymer Sci & Technol, Xian 710129, Shaanxi, Peoples R China
3.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Organ Solids, Beijing 100190, Peoples R China
4.Natl Ctr Nanosci & Technol China, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
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