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题名: An easy-to-use wound dressing gelatin-bioactive nanoparticle gel and its preliminary in vivo study
作者: Wang, Chen1, 2; Zhu, Feiyan2; Cui, Yang1, 2; Ren, Huihui1, 2; Xie, Yue1; Li, Ailing1; Ji, Lijun3; Qu, Xiaozhong2; Qiu, Dong1, 2; Yang, Zhenzhong1
刊名: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
发表日期: 2017
卷: 28, 期:1
收录类别: SCI
英文摘要: Beyond promoting hard tissue repairing, bioactive glasses (BGs) have also been proved to be beneficial for wound healing. Nano-scale BGs prepared by sol-gel method were found to have a better performance as they have a larger specific surface area. In this work, bioactive nanoparticles (nBPs) with mean diameter of 12 nm (BP-12) instead of conventional BGs were mixed with gelatin to form an easy-to-use hydrogel as a dressing for skin wound. It was found that the composite of BP-12 and gelatin could form a hydrogel (BP-12/Gel) under 25 degrees C, which showed pronounced thixotropy at a practically accessible shear rate, therefore become easy to be used for wound cover. In vitro, the composite hydrogel of BP-12 and gelatin had good biocompatibility with the fibroblast cells. In vivo, rapid cutaneous-tissue regeneration and tissue-structure formation within 7 days was observed in the wound-healing experiment performed in rats. This hydrogel is thus a promising easy-to-use wound dressing material.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/36330
Appears in Collections:高分子物理与化学实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
3.Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China
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