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题名: Thrombin Ultrasensitive Detection Based on Chiral Supramolecular Assembly Signal-Amplified Strategy Induced by Thrombin-Binding Aptamer
作者: Shen, Gang1; Zhang, Hong1; Yang, Chunrong2; Yang, Qianfan2; Tang, Yalin1
刊名: ANALYTICAL CHEMISTRY
发表日期: 2017-01-03
卷: 89, 期:1, 页:548-551
收录类别: SCI
英文摘要: Thrombin plays a critical role in hemostasis and hemolysis. It is of high importance to develop a system toward thrombin detection with high sensitivity and high selectivity for both research and clinical diagnosis applications. In this paper, we developed a thrombin detection assay by taking advantage of the novel signal amplified strategy based on the chiral supramolecular assembly in physiological K background. This assay could detect thrombin as low concentration as about 2 pM and provided a highly specific selectivity among several common interferences. Furthermore, the assay can discriminate thrombin from other nonspecific analogous proteins with high selectivity and can be used to detect thrombin in diluted real human serum samples, which suggested its great potential for rapid detection of thrombin in the clinic.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/36323
Appears in Collections:分子动态与稳态结构实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Natl Lab Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Ctr Mol Sci,Inst Chem, Beijing 100190, Peoples R China
2.Sichuan Univ, Coll Chem, Chengdu 610065, Peoples R China
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