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题名: Fabrication of Mesoporous Silica Nanoparticle with Well-Defined Multicompartment Structure as Efficient Drug Carrier for Cancer Therapy in Vitro and in Vivo
作者: Wang, Anhe1; Yang, Yang1; Qi, Yanfei3; Qi, Wen3; Fei, Jinbo2; Ma, Hongchao2; Zhao, Jie2; Cui, Wei2; Li, Junbai1, 2
关键词: silica particles ; vaterite particles ; multicompartment structure ; drug carrier ; cancer therapy
刊名: ACS APPLIED MATERIALS & INTERFACES
发表日期: 2016-04-13
卷: 8, 期:14, 页:8900-8907
收录类别: SCI
英文摘要: Vaterite particles are composed of particulate CaCO3 nano particles, which offer an ideal platform to synthesize architectures with hierarchical structure. Herein we show that mesoporous silica particles with well-defined multicompartment structure are fabricated by employing vaterite particles as templates. The obtained silica particles inherited the structure feature of vaterite and had excellent biocompatibility and biodegradability. Moreover, the silica particles were established as an efficient anticancer drugs carrier compared with hollow silica particles, which could be applied in cancer therapy in vitro and in vivo. The silica particles obtained here offer a cheap, facile, environmentally friendly avenue to assembly of hierarchical drugs carriers.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/36104
Appears in Collections:胶体、界面与化学热力学实验室_期刊论文

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作者单位: 1.Natl Ctr Nanosci & Technol, CAS Key Lab Biol Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Chem, Key Lab Colloid & Interface Sci, BNLMS, Beijing 100190, Peoples R China
3.Jilin Univ, Sch Publ Hlth, Changchun 130021, Peoples R China
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