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题名: Photophysical, G-quadruplex DNA binding and cytotoxic properties of terpyridine complexes with a naphthalimide ligand
作者: Ou, Zhize1; Qian, Yimeng1; Gao, Yunyan1; Wang, Yunqing1; Yang, Guoqiang2; Li, Yi3; Jiang, Kaiyue1; Wang, Xin1
刊名: RSC ADVANCES
发表日期: 2016
卷: 6, 期:43, 页:36923-36931
收录类别: SCI
英文摘要: Two novel metal complexes 2-3 (metal = Pd-II, Pt-II) have been synthesized by reacting the corresponding tolylterpyridine complexes and the 4-aminonaphthalimide derivative 1. The interactions of the complexes with duplex DNA and telomeric G-quadruplex DNA have been investigated by UV-Vis spectroscopy and fluorescence spectroscopy. The studies reveal that the complexes 2-3 possess high affinity and reasonable selectivity for telomeric G-quadruplex DNA over duplex DNA. Spectroscopic and molecular docking studies suggest that the complexes 2-3 interact with telomeric G-quadruplex DNA mainly through groove binding. The compounds 1-3 are emissive (Phi(em) > 0.22), making it possible to study the localization of 1-3 in A549 using fluorescence microscopy. The complexes 2-3 are mainly localized in nuclei, while 1 is localized in the nuclei and cytoplasmic region after 0.5 h incubation. The complex 3 inhibits A549 cells selectively over non-cancerous NIH3T3 cells, with higher antitumor activity than 1 and cisplatin.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/36083
Appears in Collections:光化学实验室_期刊论文

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作者单位: 1.Northwestern Polytech Univ, Dept Appl Chem, Sch Sci, Key Lab Space Appl Phys & Chem,Minist Educ, Xian 710072, Peoples R China
2.Chinese Acad Sci, Inst Chem, CAS Key Lab Photochem, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Conves & Optoelect Mat, Beijing 100190, Peoples R China
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