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题名: Synergistic Effect of Human Serum Albumin and Fullerene on Gd-DO3A for Tumor-Targeting Imaging
作者: Zhang, Ying1, 2; Zou, Toujun1, 2; Guan, Mirong1, 2; Zhen, Mingming1; Chen, Daiqin1, 2; Guan, Xiangping3; Han, Hongbin3; Wang, Chunru1; Shu, Chunying1
关键词: fullerene ; macromolecular MRI contrast agent ; contrast enhancement ; tumor-targeting imaging ; low toxicity
刊名: ACS APPLIED MATERIALS & INTERFACES
发表日期: 2016-05-11
卷: 8, 期:18, 页:11246-11254
收录类别: SCI
英文摘要: A macromolecular magnetic resonance imaging (MRI) contrast agent was successfully synthesized by conjugating the gadolinium/1,4,7,10-tetraazacydododecane-1,4,7-tetracetic acid complex (Gd-DO3A) with 6,6-phenyl-C-61 butyric acid (PC(61)BA) and upon further modification with human serum albumin (HSA). The final product, PC(61)BA-(Gd-DO3A)/HSA, has a high stability and exhibits a much higher relaxivity (r(1) = 89.1 mM(-1) s(-1) at 0.5 T, 300 K) than Gd-DO3A (r(1) = 4.7 mM(-1) s(-1)) does under the same condition, producing the synergistic positive effect of HSA and C-60 on the relaxivity of Gd-DO3A. The in vivo MR images of PC(61)BA-(Gd-DO3A)/HSA-treated tumor-bearing mice show strong signal enhancement for the tumor area due to the enhanced permeability and retention effect. The maximum accumulation of PC(61)BA-(Gd-DO3A)/HSA at the tumor site was achieved at 4 h postinjection, which may guide surgery. The results from the hematology and histological observations indicate that PC(61)BA-(Gd-DO3A)/HSA has no obvious toxicity in vivo. These unique properties of PC(61)BA-(Gd-DO3A)/HSA enable them to be highly efficient for tumor-targeting MRI in vivo, possibly providing a good solution for tumor diagnosis.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/36081
Appears in Collections:分子纳米结构与纳米技术实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Peking Univ, Hosp 3, Dept Radiol, Beijing 100083, Peoples R China
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