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题名: Nd3+ sensitized dumbbell-like upconversion nanoparticles for photodynamic therapy application
作者: Xu, Bing1; Zhang, Xiao2, 3; Huang, Wenjuan1; Yang, Yijun4; Ma, Ying1; Gu, Zhanjun2, 3; Zhai, Tianyou1; Zhao, Yuliang2, 3
刊名: JOURNAL OF MATERIALS CHEMISTRY B
发表日期: 2016
卷: 4, 期:16, 页:2776-2784
收录类别: SCI
英文摘要: Better tissue penetration and lower overheating problems mean 808 nm near-infrared laser excited upconversion nanoparticles (UCNPs) have potential in bioapplications. Dumbbell-like structured NaYF4:Yb/Er@NaNdF4:Yb nanoparticles are fabricated in this work and applied in photodynamic therapy (PDT). The epitaxial growth along the c axis attributed to the large structure mismatch of NaNdF4 versus NaYF4 has been demonstrated to play a key role in the growth of the dumbbell structure. Due to better space separation in this structure, energy back-transfer from Er3+ to Nd3+ is prohibited partially, and the optimized Nd3+ doping concentration is up to 90% for a high UC emission intensity. PDT effects of these dumbbell-like structured UCNPs upon 808 nm laser irradiation were examined and compared with isotropic NaYF4:Yb/Er@NaYF4:Nd-0.2 core-shell and NaYF4:Yb/Er@NaYF4:Nd-0.2@NaYF4 core-shell-shell UCNPs. The results show that the dumbbell-like UCNPs are most effective in generating singlet oxygen (O-1(2)) and killing cancer cells in PDT though their UC emission intensity is lower than that of the core-shell-shell UCNPs. This research presents a simple yet valid strategy to balance the UCL efficiency and FRET efficiency, which may lead to better PDT therapeutic effect for cancer therapy.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/36069
Appears in Collections:光化学实验室_期刊论文

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作者单位: 1.Huazhong Univ Sci & Technol, Sch Mat Sci & Engn, State Key Lab Mat Proc & Die & Mould Technol, Wuhan 430074, Peoples R China
2.Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Inst Chem, CAS Key Lab Photochem, BNLMS, Beijing 100190, Peoples R China
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