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题名: Macrophage Cell Membrane Camouflaged Au Nanoshells for in Vivo Prolonged Circulation Life and Enhanced Cancer Photothermal Therapy
作者: Xuan, Mingjun1, 2; Shao, Jingxin1, 3; Dai, Luru3; Li, Junbai2; He, Qiang1
关键词: macrophage cell membrane ; biostealth coating ; Au nanoshell ; long circulation ; photothermal therapy
刊名: ACS APPLIED MATERIALS & INTERFACES
发表日期: 2016-04-20
卷: 8, 期:15, 页:9610-9618
收录类别: SCI
英文摘要: Macrophage cell membrane (MPCM)-camouflaged gold nano shells (AuNS) that can serve as a new generation of photothermal conversion agents for in vivo photothermal cancer therapy are presented. They are constructed by the fusion of biocompatible AuNSs and MPCM vesicles. The resulting MPCM-coated AuNSs exhibited good colloidal stability and kept the original near-infrared (NIR) adsorption of AuNSs. Because AuNS carried high density coverage of MPCMs, the totally functional portions of macrophage cells membrane were grafted onto the surface of AuNSs. This surface functionalization provided active targeting ability by recognizing tumor endothelium and thus improved tumoritropic accumulation compared to the red blood cell membrane coating approach. These biomirnetic nanoparticles significantly enhance in vivo blood circulation time and local accumulation at the tumor when administered systematically. Upon NIR laser irradiation, local heat generated by the MPCM-coated AuNS achieves high efficiency to suppress tumor growth and selectively ablate cancerous cells within the illuminated zone. Therefore, MPCM-coated AuNSs remained the natural properties of their source cells, which may improve the efficacy of photothermal therapy modulated by AuNSs and other noble-metal nanoparticles.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/36043
Appears in Collections:胶体、界面与化学热力学实验室_期刊论文

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作者单位: 1.Harbin Inst Technol, Micro Nanotechnol Res Ctr, Minist Educ, Key Lab Microsyst & Microstruct Mfg, Harbin 150080, Peoples R China
2.Chinese Acad Sci, Inst Chem, Key Lab Colloid Interface & Chem Thermodynam, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
3.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China
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