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题名: Fabrication of a mercaptoacetic acid pillar[5]arene assembled nanochannel: a biomimetic gate for mercury poisoning
作者: Zhang, Fan1; Ma, Junkai1; Sun, Yue1; Boussouar, Imene1; Tian, Demei1; Li, Haibing1, 2; Jiang, Lei2
刊名: CHEMICAL SCIENCE
发表日期: 2016
卷: 7, 期:5, 页:3227-3233
收录类别: SCI
英文摘要: Mercury ion binding blocks potassium ion channels, which leads to toxicity in vivo. It is challenging to design a simple and efficient artificial system to mimic the sophisticated biological process of mercury poisoning. Herein, based on biomimetic strategies, a tunable mercury(II) ion-gate modulated by mercaptoacetic acid-pillar[5] arene (MAP5) is reported. By virtue of the unique design of the host-guest competition, potassium ion transport can actualize the reversible switching between "on" and "off" in the absence and presence of mercury ions. Moreover, the MAP5-immobilized nanochannel is highly effective at distinguishing Hg2+ from other metal ions and can be used to detect Hg2+ and act as an excellent and robust gate valve for developing integrated circuits and nanoelectronic logic devices. This study paves a new way for better understanding the physiological phenomenon of mercury toxicity and shows great promise for biomedical research.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/36038
Appears in Collections:有机固体实验室_期刊论文

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作者单位: 1.Cent China Normal Univ, Minist Educ, Coll Chem, Key Lab Pesticide & Chem Biol CCNU, Wuhan 430079, Peoples R China
2.Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, BNLMS, Beijing 100190, Peoples R China
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