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题名: Kinesin-1 inhibits the aggregation of amyloid-beta peptide as detected by fluorescence cross-correlation spectroscopy
作者: Zheng, Yanpeng1; Tian, Shijun1; Peng, Xianglei1; Yang, Jingfa2; Fu, Yuanhui1; Jiao, Yueying1; Zhao, Jiang2; He, Jinsheng1; Hong, Tao1, 3
关键词: Alzheimer's disease ; amyloid beta ; fluorescence cross-correlation spectroscopy ; kinesin-1
刊名: FEBS LETTERS
发表日期: 2016-04-01
卷: 590, 期:7, 页:1028-1037
收录类别: SCI
英文摘要: Although the exact etiology and pathogenesis of Alzheimer's disease (AD) are still unclear, amyloid-beta (A beta) generated by the proteolytic processing of amyloid-b precursor protein (APP) aggregate to form toxic amyloid species. Kinesin-1 is the first identified ATP-dependent axonal transport motor protein that has been proven to affect A beta generation and deposition. In this paper, we applied dual-color fluorescence cross-correlation spectroscopy (DC-FCCS) to investigate the direct interaction of A beta with kinesin-1 at the single-molecule fluorescence level in vitro. The results showed that two kinds of enhanced green fluorescent protein (EGFP)-tagged kinesin light-chain subunits of kinesin-1(KLCs), KLC-E and E-KLC inhibited the aggregation of A beta over a period of time, providing additional insight into the mechanism of axonal transport deficits in AD.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/36002
Appears in Collections:高分子物理与化学实验室_期刊论文

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作者单位: 1.Beijing Jiaotong Univ, Coll Life Sci & Bioengn, Beijing 100044, Peoples R China
2.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
3.Chinese Ctr Dis Control & Prevent, Inst Viral Dis Control & Prevent, Beijing, Peoples R China
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