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题名: Efficient Synthesis of Ionic Triblock Copolyesters and Facile Access to Charge-Reversal Hybrid Micelles
作者: Wu, Shaohua1, 2; Zheng, Liuchun1; Zhou, Wen3; Li, Chuncheng1; Xiao, Yaonan1; Zhu, Wenxiang1
关键词: aliphatic copolyester ; amphiphiles ; charge-reversal ; click reaction ; micelles ; stimuli-sensitive polymers
刊名: JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
发表日期: 2016-05-01
卷: 54, 期:9, 页:1259-1267
收录类别: SCI
英文摘要: Novel carboxyl-and amino-functionalized copolyesters, based on poly(e-caprolactone)-block-poly(butylene fumarate)-block-poly(epsilon-caprolactone), were efficiently synthesized via Michael-type thiol-ene click chemistry. The resulting amphiphilic copolyesters with controllable molecular weights and abundant positively or negatively charged groups could spontaneously form pH-sensitive micelles in aqueous solutions, as confirmed by transmission electron microscopy, dynamic light scattering, fluorescence probing technique, and zeta potential analyses. Importantly, charge-reversal hybrid micelles can be obtained by co-assembly of carboxyl- and amino-functionalized copolyesters. The surface charges of hybrid micelles reversed rapidly from negative to positive at isoelectric point via protonation of surface carboxyl and amino groups. Interestingly, the hybrid micelles showed apparent pH-triggered Nile red-release behavior in acidic condition resembling tumor intracellular environment, which is fairly desirable for drug delivery. Our work indicates that co-assembly is a facile but efficient way to prepare charge-reversal micelles, which have great potential to be used as intelligent drug delivery systems for cancer therapy. (C) 2015 Wiley Periodicals, Inc.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35992
Appears in Collections:工程塑料实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Key Lab Engn Plast, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Inst Chem Def, Beijing 102205, Peoples R China
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