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题名: Fluorinated Radicamine A and B: Synthesis and Glycosidase Inhibition
作者: Li, Yi-Xian1; Iwaki, Ren2; Kato, Atsushi2; Jia, Yue-Mei1; Fleet, George W. J.3, 6; Zhao, Xuan1; Xiao, Min4, 5; Yu, Chu-Yi1, 6
关键词: Azasugars ; Iminosugar ; Fluorine ; Inhibitors ; Structure-activity relationships ; Drug design
刊名: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
发表日期: 2016-03-01
期: 7, 页:1429-1438
收录类别: SCI ; IC
英文摘要: Fluorinated derivatives of radicamine A and radicamine B have been synthesized from D-arabinose-derived cyclic nitrone. Structure-activity relationship studies showed that glycosidase inhibition of these fluorinated derivatives was significantly influenced by the position of the fluorine atom. C-7 or C-11 fluorination of the aromatic ring decreased alpha-glucosidase inhibition of the derivatives, whereas C-8 or C-10 fluorination preserved glycosidase inhibitory activities.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35947
Appears in Collections:分子识别与功能实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, Key Lab Mol Recognit & Funct, BNLMS, Beijing 100190, Peoples R China
2.Toyama Univ, Dept Hosp Pharm, 2630 Sugitani, Toyama 9300194, Japan
3.Univ Oxford, Dept Chem, Chem Res Lab, Mansfield Rd, Oxford OX1 3TA, England
4.Shandong Univ, State Key Lab Microbial Technol, Jinan 250100, Peoples R China
5.Shandong Univ, Natl Glycoengn Res Ctr, Jinan 250100, Peoples R China
6.Jiangxi Normal Univ, Natl Engn Res Ctr Carbohydrate Synth, Nanchang 330022, Peoples R China
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