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题名: Intercellular Connections Related to Cell-Cell Crosstalk Specifically Recognized by an Aptamer
作者: Zhang, Nan1, 2; Bing, Tao1; Shen, Luyao1, 2; Song, Rusheng1, 2; Wang, Linlin1, 2; Liu, Xiangjun1; Liu, Meirong1; Li, Juan3, 4, 5; Tan, Weihong3, 4, 5; Shangguan, Dihua1
关键词: aptamers ; cell communication ; fluorescent probes ; intercellular connections ; tunneling nanotubes
刊名: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
发表日期: 2016-03-14
卷: 55, 期:12, 页:3914-3918
收录类别: SCI
英文摘要: Intercellular connections are an important pathway for cell-cell crosstalk. However, their formation mechanism and functions are far from being understood. The lack of molecular probes hampers the research in this area. Herein, we report a kind of intercellular connection that is specifically recognized by aptamer M17A2 generated by cell-SELEX against MCF-7R cells. These connections have different morphologies, but have the same skeleton composed of F-actin. The long filamentous connections were identified to be tunneling nanotubes (TNTs), a recently discovered cell-cell communication route. These connections could be built not only between MCF-7R cells, but also from MCF-7R to other cells after co-culture. Proteins could be transported between cells through these connections, suggesting their cell communication function. Aptamer M17A2 shows the potential to act as a new probe for investigating this kind of intercellular connection, as well as for studying cell-cell communication.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35944
Appears in Collections:活体分析化学实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Univ Florida, Ctr Res Bio Nano Interface, Hlth Canc Ctr, Genet Inst,McKnight Brain Inst, Gainesville, FL 32611 USA
4.Hunan Univ, Coll Biol, State Key Lab Chemo Biosensing & Chemometr, Mol Sci & Biomed Lab, Changsha 410082, Hunan, Peoples R China
5.Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China
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