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题名: Cationic Conjugated Polymers-Induced Quorum Sensing of Bacteria Cells
作者: Zhang, Pengbo1; Lu, Huan1; Chen, Hui1; Zhang, Jiangyan1; Liu, Libing1; Lv, Fengting1; Wang, Shu1
刊名: ANALYTICAL CHEMISTRY
发表日期: 2016-03-15
卷: 88, 期:6, 页:2985-2988
收录类别: SCI
英文摘要: Bacteria quorum sensing (QS) has attracted significant interest for understanding cell cell communication and regulating biological functions. In this work, we demonstrate that water-soluble cationic conjugated polymers (PFP-G2) can interact with bacteria to form aggregates through electrostatic interactions. With bacteria coated in the aggregate, PFP-G2 can induce the bacteria QS system and prolong the time duration of QS signal molecules (autoinducer-2 (AI-2)) production. The prolonged AI-2 can bind with specific protein and continuously regulate downstream gene expression. Consequently, the bacteria show a higher survival rate against antibiotics,: resulting in decreased antimicrobial susceptibility. Also, AI-2 induced by PFP-G2 can stimulate 55.54 +/- 12.03% more biofilm in E. coli. This method can be used to understand cell cell communication and regulate biological functions, such as the production of signaling molecules, antibiotics, other microbial metabolites, and even virulence.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35926
Appears in Collections:有机固体实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
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