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题名: pH gradient difference around ischemic brain tissue can serve as a trigger for delivering polyethylene glycol-conjugated urokinase nanogels
作者: Cui, Wei1; Liu, Ran1; Jin, Haiqiang1; Lv, Pu1; Sun, Yuyao1; Men, Xi1; Yang, Saina2; Qu, Xiaozhong3; Yang, Zhenzhong2; Huang, Yining1
关键词: Nanodrug ; Activity manipulation ; Targeted release ; Thrombolysis ; Blood-brain barrier
刊名: JOURNAL OF CONTROLLED RELEASE
发表日期: 2016-03-10
卷: 225, 页:53-63
收录类别: SCI
英文摘要: Background and Purpose: pH-sensitive polyethylene glycol-conjugated urokinase nanogels (PEG-UKs) were previously reported to be a new form of UK nanogels that could release UK at certain pH values. In this study, we evaluated the effect of PEG-UK targeted to ischemic tissue with microcirculation failure in rat model of ischemic stroke and investigated the possible mechanisms of action.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35863
Appears in Collections:高分子物理与化学实验室_期刊论文

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作者单位: 1.Peking Univ, Dept Neurol, Hosp 1, Beijing 100034, Peoples R China
2.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Coll Mat & Optoelect Technol, Beijing 100049, Peoples R China
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