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题名: Selective Antimicrobial Activities and Action Mechanism of Micelles Self-Assembled by Cationic Oligomeric Surfactants
作者: Zhou, Chengcheng1; Wang, Fengyan2; Chen, Hui2; Li, Meng2; Qiao, Fulin1; Liu, Zhang1; Hou, Yanbo1; Wu, Chunxian1; Fan, Yaxun1; Liu, Libing2; Wang, Shu2; Wang, Yilin1
关键词: cationic micelle ; hexameric surfactant ; tetrameric surfactant ; trimeric surfactant ; antimicrobial activity ; action mechanism
刊名: ACS APPLIED MATERIALS & INTERFACES
发表日期: 2016-02-17
卷: 8, 期:6, 页:4242-4249
收录类别: SCI
英文摘要: This work reports that cationic micelles formed by cationic trimeric, tetrameric, and hexameric surfactants bearing amide moieties in spacers can efficiently kill Gram-negative E. coli with a very low minimum inhibitory concentration (1.70-0.93 mu M), and do not cause obvious toxicity to mammalian cells at the concentrations used. With the increase of the oligomerization degree, the antibacterial activity of the oligomeric surfactants increases, i.e., hexameric surfactant > tetrameric surfactant > trimeric surfactant. Isothermal titration microcalorimetry, scanning electron microscopy, and zeta potential results reveal that the cationic micelles interact with the cell membrane of E. coli through two processes. First, the integrity of outer membrane of E. coli is disrupted by the electrostatic interaction of the cationic ammonium groups of the surfactants with anionic groups of E. coli, resulting in loss of the barrier function of the outer membrane. The inner membrane then is disintegrated by the hydrophobic interaction of the surfactant hydrocarbon chains with the hydrophobic domains of the inner membrane, leading to the cytoplast leakage. The formation of micelles of these cationic oligomeric surfactants at very low concentration enables more efficient interaction with bacterial cell membrane, which endows the oligomeric surfactants with high antibacterial activity.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35851
Appears in Collections:有机固体实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, BNLMS, Key Lab Colloid & Interface Sci, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Chem, BNLMS, Key Lab Organ Solids, Beijing 100190, Peoples R China
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