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题名: No Effect of Rapamycin on Cardiac Adhesion Formation: A Drug-Loaded Bioresorbable Polylactone Patch in a Porcine Cardiac Surgical Model
作者: Qazi, Saddiq2; Kjaergaard, Benedict2, 4, 5; Yang, Eel1; Shen, Hong1; Wang, Shenguo1; Zhang, Navee1; Vyberg, Mogens3, 4; Woyen, Arne3; Andreasen, Jan Jesper2, 4
关键词: Adhesion ; Cardiac surgery ; Patch ; Pigs ; Rapamycin
刊名: EUROPEAN SURGICAL RESEARCH
发表日期: 2016
卷: 56, 期:1-2, 页:76-85
收录类别: SCI
英文摘要: Background: The fusing of the epicardium and sternum due to adhesion is a common problem during repeated cardiac surgery and carries with it an increased risk of bleeding. The use of barriers and patches has been tested to prevent the formation of adhesions, but the very presence of a patch can provoke adhesion formation. The objective of this study was, therefore, to investigate both biodegradable and bioresorbable polylactone patches [(polycaprolactonepoly(ethylene oxide)-polycaprolactone tri-block copolymer (PCE)]. The patches were also tested with a controlled release of rapamycin, which prevents cell migration and extracellular matrix deposition. The clinical effectiveness of rapamycin in pericardial patches has not previously been examined. Materials and Methods: Three groups of 6 female Danish Landrace pigs underwent sternotomy and abrasion of the epicardium, before being randomized to either group 1 - the control group (with no patch), group 2 - PCE patch implanted between the sternum and epicardium, or group 3 - PCE patch and slow-release 1.6-mg rapamycin. After a median time period of 26 days, the pigs were euthanized and their hearts removed en bloc with the sternum, for macroscopic, histological and pathological examination. Results: Upon macroscopic examination, a significantly lower degree of adhesion in group 2, as compared to group 1 (p < 0.05), was found. Histological analysis of the tissues showed significantly more fibrosis, inflammation and foreign body granulomas (p < 0.05) in both group 2 and group 3, when compared to group 1. Conclusion: A PCE patch following sternotomy in animal subjects reduces postoperative macroscopic adhesions without reducing microscopic fibrosis or inflammation. Loading the patch with rapamycin was found not to increase the antifibrotic effect. (C) 2016 S. Karger AG, Basel
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35828
Appears in Collections:高分子物理与化学实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
2.Aalborg Univ Hosp, Dept Cardiothorac Surg, Aalborg, Denmark
3.Aalborg Univ Hosp, Inst Pathol, Aalborg, Denmark
4.Aalborg Univ Hosp, Dept Clin Med, Aalborg, Denmark
5.Aalborg Univ Hosp, Biomed Res Lab, Aalborg, Denmark
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