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题名: Gelatin-Assisted Synthesis of Vaterite Nanoparticles with Higher Surface Area and Porosity as Anticancer Drug Containers In Vitro
作者: Wang, Anhe1; Yang, Yang1; Zhang, Xiaoming1; Liu, Xingcen2; Cui, Wei2; Li, Junbai2
关键词: doxorubicin ; drug delivery ; gelatin-assisted synthesis ; pH-responsive materials ; vaterite nanoparticles
刊名: CHEMPLUSCHEM
发表日期: 2016-02-01
卷: 81, 期:2, 页:194-201
收录类别: SCI
英文摘要: The fabrication of porous vaterite nanoparticles with improved stability in aqueous solution and higher surface area is still a challenge. Here, inspired by the formation of mesoporous silica nanoparticles, we have taken gelatin as a surfactant to assist in the formation of vaterite nanoparticles and help create pores on their surface due to the distinct solubility and molecular morphology of gelatin in different solutions. The formation mechanism of vaterite nanoparticles and pores was investigated in detail, indicating that the existence of gelatin has a crucial effect on the formation of vaterite nanoparticles and their stability. Meanwhile, the elution of gelatin from vaterite nanoparticles via washing with hot water accounts for their higher surface area. Their application as an anticancer drug (doxorubicin) carrier after folic acid treatment was also investigated. These nanoparticles have advantages for drug release due to their pH-sensitive structure and also have enhanced cytotoxicity toward cancer cells due to the folic acid modification.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35819
Appears in Collections:胶体、界面与化学热力学实验室_期刊论文

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作者单位: 1.Natl Ctr Nanosci & Technol, Bei Yi Tiao 11, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Key Lab Colloid Interface & Chem Thermodynam, Inst Chem, Bei Yi Jie 2, Beijing 100190, Peoples R China
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