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题名: Synthesis and Properties of Hemostatic and Bacteria-Responsive in Situ Hydrogels for Emergency Treatment in Critical Situations
作者: Bu, Yazhong1; Zhang, Licheng2; Liu, Jianheng2; Zhang, Lihai2; Li, Tongtong2; Shen, Hong1; Wang, Xing1; Yang, Fei1; Tang, Peifu2; Wu, Decheng1
关键词: PEG ; hydrogels ; hemostasis ; antibacteria ; pH-responsive
刊名: ACS APPLIED MATERIALS & INTERFACES
发表日期: 2016-05-25
卷: 8, 期:20, 页:12674-12683
收录类别: SCI
英文摘要: Immediate hemorrhage control and infection prevention are pivotal for saving lives in critical situations such as battlefields, natural disasters, traffic accidents, and so on. In situ hydrogels are promising candidates, but their mechanical strength is often not strong enough for use in critical situations. In this study, we constructed three hydrogels with different amounts of Schiff-base moieties from 4-arm-PEGNH2, 4-arm-PEG-NHS, and 4-arm-PEG-CHO in which vancomycin was incorporated as an antimicrobial agent. The hydrogels possess porous structures, excellent mechanical strength, and high swelling ratio. The cytotoxicity studies indicated that the composite hydrogel systems possess good biocompatibility. The Schiff bases incorporated improve the adhesiveness and endow the hydrogels with bacteria-sensitivity. The in vivo hemostatic and antimicrobial experiments on rabbits and pigs demonstrated that the hydrogels are able to aid in rapid hemorrhage control and infection prevention. In summary, vancomycin-loaded hydrogels may be hemostatic and antibacterial materials for first aid treatment of the wounded in critical situations.excellent candidates as
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35765
Appears in Collections:高分子物理与化学实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Orthopaed, Beijing 100853, Peoples R China
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