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题名: Facile fabrication of robust polydopamine microcapsules for insulin delivery
作者: Li, Hong1; Jia, Yi2; Feng, Xiyun2; Li, Junbai2
关键词: Polydopamine microcapsules ; Oxidative self-polymerization ; Insulin ; pH-responsive release
刊名: JOURNAL OF COLLOID AND INTERFACE SCIENCE
发表日期: 2017-02-01
卷: 487, 页:12-19
收录类别: SCI
英文摘要: Inspired by the composition of adhesive proteins in mussel, a facile, low-cost, and green approach to construct robust polydopamine (PDA) microcapsules as carriers for insulin delivery is developed. The morphology and shell thickness of the capsules could be tuned by varying the concentration of dopamine or the pH of Tris-HCI buffer. The PDA capsules are stable enough for long-term storage and transportation in practical application. The fluorescent property of PDA capsules labeled with FITC is beneficial in monitoring the safety and efficacy of drug carriers. Furthermore, the PDA shell coated insulin particles exhibit pH-responsive release behavior, making them promising for the oral administration of insulin in diabetic patients. (C) 2016 Elsevier Inc. All rights reserved.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35692
Appears in Collections:胶体、界面与化学热力学实验室_期刊论文

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作者单位: 1.Xian Shiyou Univ, Sch Chem & Chem Engn, Xian 710065, Peoples R China
2.Chinese Acad Sci, Inst Chem, Key Lab Colloid Interface & Chem Thermodynam, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
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