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题名: Self-Aggregation, Antibacterial Activity, and Mildness of Cyclodextrin/Cationic Trimeric Surfactant Complexes
作者: Zhou, Chengcheng1, 3; Wang, Dong4; Cao, Meiwen4; Chen, Yao1, 3; Liu, Zhang1, 3; Wu, Chunxian1, 3; Xu, Hai4; Wang, Shu2; Wang, Yilin1, 3
关键词: cyclodextrin ; cationic trimeric surfactant ; aggregation behavior ; antimicrobial activities ; mildness
刊名: ACS APPLIED MATERIALS & INTERFACES
发表日期: 2016-11-16
卷: 8, 期:45, 页:30811-30823
收录类别: SCI
英文摘要: Despite efficacious antimicrobial activity, cationic oligomeric surfactants show strong skin irritation potential due to their larger cationic charge numbers and multiple hydrophobic chains. This work reports that the incorporation of alpha-, beta-, and gamma-CDs with different cavity sizes can effectively improve the mildness of cationic ammonium trimeric surfactant DTAD with a star-shaped spacer while maintaining its high antibacterial activity. On the basis of the different cavity sizes of CDs and the asymmetry in the spacer of DTAD, the CD/DTAD mixtures form alpha-CD@DTAD, 2 alpha-CD@DTAD, beta-CD@DTAD, and gamma-CD@DTAD complexes. Compared to DTAD, these CD/DTAD complexes show much stronger self-assembly ability with much lower critical aggregation concentrations (CAC) and form more diverse aggregates with reduced zeta potential. Just above their CACs, the CD/DTAD complexes form vesicles or solid spherical aggregates of similar to 50 nm and then transform into small micelles of similar to 10 nm as the concentration increases. The strong self-assembly ability and the multiple sites of hydrogen bonds of the CD/DTAD complexes endow them with high antibacterial activity against E. coli, showing a very low minimum inhibitory concentration (2.22-2.48 mu M) comparable to that of DTAD. In particular, the addition of CDs significantly reduces the abilities of DTAD in solubilizing zein (a skin model protein) and in binding with zein, and the mildness decreases in the order of 2 alpha-CD@DTAD > beta-CD@DTAD > gamma-CD@DTAD > alpha-CD@DTAD. This tendency depends on their different self-assembling structures, and the formation of vesicles is approved to be in favor of the improvement of the mildness.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35684
Appears in Collections:胶体、界面与化学热力学实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, BNLMS, Key Lab Colloid & Interface Sci, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, BNLMS, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.China Univ Petr East China, Ctr Bioengn & Biotechnol, Qingdao 266580, Peoples R China
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