中国科学院化学研究所机构知识库
Advanced  
ICCAS OpenIR  > 高分子物理与化学实验室  > 期刊论文
题名: Nano-rods of doxorubicin with poly(L-glutamic acid) as a carrier-free formulation for intratumoral cancer treatment
作者: Yang, Saina1; Zhu, Feiyan2; Wang, Qian1; Liang, Fuxin1; Qu, Xiaozhong1, 2; Gan, Zhihua3; Yang, Zhenzhong1
刊名: JOURNAL OF MATERIALS CHEMISTRY B
发表日期: 2016-12-07
卷: 4, 期:45, 页:7283-7292
收录类别: SCI
英文摘要: In addition to intravenous injections (i.v.), topical dosing of doxorubicin hydrochloride (DOX) has also been the focus of cancer treatment recently, although it normally requires well-designed drug carriers. In this work, we found that DOX could form fibril-shaped DOX aggregates via self-assembly in phosphate buffer (PB) and then co-assemble with poly(L-glutamic acid) (PGA) at a proper polymer-drug ratio, giving a unique nano-rod-shaped microstructure. The release rate of DOX from the PGA/DOX nano-rods was thus easily controlled at a slower release rate without being encapsulated by any classic carrier. In vitro cell culture demonstrated that the PGA/DOX nano-rods were not favorably taken up by cancer cells, which can be attributed to the negatively charged nature and the non-spherical shape of the aggregates. These features suggest great potential for the PGA/DOX assemblies for a sustained delivery through the intratumoral pathway (i.t.) as a carrier-free formulation. In the mouse model it diminished organ damage at a dose level of 30 mg kg(-1) via i.t. injections compared to the serious cardiotoxicity and renal toxicity via typical multiple i.v. dosage of free drug solution at 5 mg kg(-1). As a result, the PGA/DOX formulation showed efficient anti-tumor activity. The survival rate of tumor bearing mice was significantly increased by over 35% compared to the i.v. injections of DOX solutions. Therefore, PGA/DOX nano-rods may provide a new and safe delivery route of the common anti-tumor drug.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35678
Appears in Collections:高分子物理与化学实验室_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China
3.Beijing Univ Chem Technol, Coll Life Sci & Technol, Beijing 100029, Peoples R China
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yang, Saina]'s Articles
[Zhu, Feiyan]'s Articles
[Wang, Qian]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yang, Saina]‘s Articles
[Zhu, Feiyan]‘s Articles
[Wang, Qian]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院化学研究所 - Feedback
Powered by CSpace