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题名: A mitochondria targeting Mn nanoassembly of BODIPY for LDH-A, mitochondria modulated therapy and bimodal imaging of cancer
作者: Boison, Daniel1, 2, 4; Lu, Wen-Long1; Xu, Qin-Mei3; Yang, Huang1; Huang, Tao2; Chen, Qiu-Yun1; Gao, Jing2; Zhao, Yao5
关键词: Anticancer ; Manganese nanoparticle ; Mitochondria ; Apoptosis ; Imaging
刊名: COLLOIDS AND SURFACES B-BIOINTERFACES
发表日期: 2016-11-01
卷: 147, 页:387-396
收录类别: SCI
英文摘要: HIF-1 alpha and LDH-A are important targets for hypoxia-driven drug resistance. Mitochondria targeted fluorescent manganese(II)-complexes can be used as potential fluorescence imaging agents, MRI contrast agents and HIF-1 alpha and LDH-A involved anticancer complexes. In this study, a fluorescent manganese(II) nanoparticle, labeled as (PEG-Mn-BDA), was synthesized and used as both fluorescent and MRI imaging agents in cancer cells. In vitro bioassay results indicate that PEG-Mn-BDA was able to inhibit LDH-A activity and depolarize mitochondrial membrane potential with the generation of intracellular ROS, which contributed to the induction of apoptosis. Moreover, the pro-apoptotic protein, caspase 3 was highly expressed. In vivo, PEG-Mn-BDA could also exert inhibition on a mouse hepatocellular carcinoma xenograft. These results suggest that mitochondria targeted PEG-Mn-BDA was able to simultaneously induce selective inhibition on cancer cells and a mouse carcinoma xenograft, label cancer cells with fluorescence and enhance MRI contrast. Therefore, PEG-Mn-BDA is a good candidate for cancer treatment and imaging. (C) 2016 Elsevier B.V. All rights reserved.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35667
Appears in Collections:活体分析化学实验室_期刊论文

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作者单位: 1.Jiangsu Univ, Sch Chem & Chem Engn, Zhenjiang 212013, Peoples R China
2.Jiangsu Univ, Sch Pharm, Zhenjiang 212013, Peoples R China
3.Southeast Univ, Zhongda Hosp, Sch Med, Jiangsu Key Lab Mol & Funct Imaging,Dept Radiol, Nanjing 210009, Peoples R China
4.Univ Cape Coast, Sch Biol Sci, Dept Biochem, Cape Coast, Ghana
5.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, CAS Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China
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