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ICCAS OpenIR  > 分子纳米结构与纳米技术实验室  > 期刊论文
题名: Gd@C-82-(ethylenediamine)(8) Nanoparticle: A New High-Efficiency Water -Soluble ROS Scavenger
作者: Li, Jie1, 2; Guan, Mirong1, 2; Wang, Taishan1; Zhen, Mingming1, 2; Zhao, Fuwen1, 2; Shu, Chunying1; Wang, Chunru1, 2
关键词: ROS scavenger ; Gd@C-82-(EDA)(8) nanoparticles ; conjugation ; cytoprotective effect ; cellular uptake
刊名: ACS APPLIED MATERIALS & INTERFACES
发表日期: 2016-10-05
卷: 8, 期:39, 页:25770-25776
收录类别: SCI
英文摘要: It is important to maintain a reactive oxygen species (ROS) balance in organisms; thus, a valid ROS scavenger with good biocompatibility is urgently required. To prepare a high-efficiency ROS scavenger, multiple ethylenediamine (EDA) groups are bonded for the first time to a metallofullerene Gd@C-82 to obtain water-soluble Gd@C-82-(EDA)(8) nanoparticles (NPs) through a facile solid liquid reaction. Gd@C-82-(EDA)(8) NPs with a relatively better conjugation possess an excellent capability to scavenge hydroxyl radicals. Moreover, Gd@C-82-(EDA)(8) NPs exhibited a remarkable cytoprotective effect against H2O2-induced injuries to human epidermal keratinocytes-adult (HEK-a) cells at a low concentration of 2.5 mu M. In contrast, Gd@C-82-(OH)(26) NPs that modified with hydroxyls show an apparent protective effect at a much higher concentration of 40 mu M. This outstanding cytoprotective performance of Gd@C-82-(EDA)(8) NPs is mainly attributed to their extremely high cellular uptake and comparably strong conjugation. Gd@C-82-(EDA)(8) NPs with good biocompatibility exhibit excellent ROS scavenging capability even at a significantly low concentration, which promotes its versatile applications in cosmetics and biomedicine.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35666
Appears in Collections:分子纳米结构与纳米技术实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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