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题名: Rational design of multi-targeting ruthenium- and platinum-based anticancer complexes
作者: Zheng, Wei1, 2, 3, 4, 5; Zhao, Yao1, 2, 3, 4, 5; Luo, Qun1, 2, 3, 4, 5; Zhang, Yang1, 2, 3, 4, 5; Wu, Kui1, 2, 3, 4, 5; Wang, Fuyi1, 2, 3, 4, 5
关键词: anticancer agents ; metal complexes ; multi-targeting ; EGFR-inhibition ; DNA binding
刊名: SCIENCE CHINA-CHEMISTRY
发表日期: 2016-10-01
卷: 59, 期:10, 页:1240-1249
收录类别: SCI
英文摘要: Platinum-based anticancer drugs, including cisplatin and its analogues, have played important roles in the clinical treatment of solid tumors over the past 38 years. However, poor selectivity, high toxicity and intrinsic or acquired drug resistance profoundly limit their application, which encourages the development of novel transition metal-based anticancer agents with different mechanisms of action. To this end, transition metal complexes that can simultaneously act on more than one target, termed as single-molecule multi-targeting complexes, have attracted increasing attention because of their enhanced efficacy and diminished chance of drug resistance. In this review, we systematically discuss the recent progress in the development of platinum- and ruthenium-based anticancer agents, in particular the rational design of platinum and ruthenium complexes with multi-targeting features.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35644
Appears in Collections:活体分析化学实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Chinese Acad Sci, CAS Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Natl Ctr Mass Spectrometry Beijing, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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