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Rational design and functional evolution of targeted peptides for bioanalytical applications
Huang, Yanyan1,2; Jin, Yulong1,2; Zhao, Rui1,2
2016-10-01
Source PublicationSCIENCE CHINA-CHEMISTRY
Volume59Issue:10Pages:1250-1257
AbstractThe complicated, highly dynamic and diverse nature of biosystems brings great challenges to the specific analysis of molecular processes of interest. Nature provides antibodies for the specific recognition of antigens, which is a straight-forward way for targeted analysis. However, there are still limitations during the practical applications due to the big size of the antibodies, which accelerate the discovery of small molecular probes. Peptides built from various optional building blocks and easily achieved by chemical synthetic approaches with predictable conformations, are versatile and can act as tailor-made targeting vehicles. In this mini review, we summarize the recent developments in the discovery of novel peptides for bioanalytical and biomedical applications. Progresses in peptide-library design and selection strategies are presented. Recent achievements in the peptide-guided detection, imaging and disease treatment are also focused.
KeywordPeptide Design Screening Targeted Analysis Biomedical Applications
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/35631
Collection活体分析化学实验室
Affiliation1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, CAS Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Huang, Yanyan,Jin, Yulong,Zhao, Rui. Rational design and functional evolution of targeted peptides for bioanalytical applications[J]. SCIENCE CHINA-CHEMISTRY,2016,59(10):1250-1257.
APA Huang, Yanyan,Jin, Yulong,&Zhao, Rui.(2016).Rational design and functional evolution of targeted peptides for bioanalytical applications.SCIENCE CHINA-CHEMISTRY,59(10),1250-1257.
MLA Huang, Yanyan,et al."Rational design and functional evolution of targeted peptides for bioanalytical applications".SCIENCE CHINA-CHEMISTRY 59.10(2016):1250-1257.
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