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题名: Interaction of hypericin with guanine-rich DNA: Preferential binding to parallel G-Quadruplexes
作者: Zhang, Xin1, 2; Jin, Bing1, 2; Zheng, Wei1; Zhang, Nan1, 2; Liu, Xiangjun1; Bing, Tao1; Wei, Yongbiao1; Wang, Fuyi1; Shangguan, Dihua1, 2
关键词: Hypericin ; G-Quadruplexes ; DNA ; Binding model ; Molecular docking
刊名: DYES AND PIGMENTS
发表日期: 2016-09-01
卷: 132, 页:405-411
收录类别: SCI
英文摘要: Hypericin (Hyp) is one of the principal active constituents of a traditional folk medicine, Hypericum (Saint John's wort), and possesses variety biological activities. The interaction of Hyp with DNA may play an important role in biological activity, however only a few investigations were reported on this issue. In this paper, we studied the interaction of Hyp with different DNA forms. Hyp was found to selectively bind parallel DNA G-Quadruplexes (G4) over other DNA forms, such as ss-/ds-DNA, antiparallel G4s and mix type G4s. Binding studies suggest that Hyp bind on G-quartet surface of G4s through end-stacking interaction. These results provide new information for the investigation of action mechanism of Hyp. (C) 2016 Elsevier Ltd. All rights reserved.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35545
Appears in Collections:活体分析化学实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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