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题名: Synthesis and characterization of PLGA nanoparticle/4-arm-PEG hybrid hydrogels with controlled porous structures
作者: Zhuang, Yaping1; Shen, Hong1; Yang, Fei1; Wang, Xing1; Wu, Decheng1
刊名: RSC ADVANCES
发表日期: 2016
卷: 6, 期:59, 页:53804-53812
收录类别: SCI
英文摘要: Controlled porous structures, adjustable surface properties and good mechanical properties are essential for hydrogels in promoting cell adhesion and growth. In this work, we developed four armed poly(ethylene glycol) (4-arm-PEG) hydrogels crosslinked by poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs). Branched polyethyleneimine (b-PEI) was employed for aminolysis of PLGA to engineer 300, 530 and 1000 nm NPs with a nitrogen contents of 11.7%, 9.4% and 9.7%. Hybrid hydrogels were formed by crosslinking amino-packed NPs with polymeric chains of 4-arm-PEG-NHS. By manipulating the NP and PEG contents as well as the NP sizes, the pore sizes could be tailored from 10-20 mu m to 20-40 mu m and 100-200 mu m, and the maximal compressive strength could be optimized to 0.37 MPa. Cytotoxicity trials indicated the hydrogels were almost non-toxic and biocompatible. Cell adhesion evaluation testified higher amino contents and a smaller proportion of PEG led to more cell attachment. These results demonstrated that this kind of hybrid hydrogel may be a suitable candidate for further biomedical applications in tissue engineering.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35540
Appears in Collections:高分子物理与化学实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
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