中国科学院化学研究所机构知识库
Advanced  
ICCAS OpenIR  > 分子纳米结构与纳米技术实验室  > 期刊论文
题名: Metformin is a novel suppressor for transforming growth factor (TGF)-beta 1
作者: Xiao, Han1, 2, 3; Zhang, Jianshu1, 2, 3; Xu, Zhonghe4; Feng, Yenan1, 2, 3; Zhang, Mingliang1, 2, 3; Liu, Jianli5; Chen, Ruifei1, 2, 3; Shen, Jing1, 2, 3; Wu, Jimin1, 2, 3; Lu, Zhizhen1, 2, 3; Fang, Xiaohong5; Li, Jingyuan4; Zhang, Youyi1, 2, 3
刊名: SCIENTIFIC REPORTS
发表日期: 2016-06-28
卷: 6
收录类别: SCI
英文摘要: Metformin is a widely used first-line antidiabetic drug that has been shown to protect against a variety of specific diseases in addition to diabetes, including cardiovascular disorders, polycystic ovary syndrome, and cancer. However, the precise mechanisms underlying the diverse therapeutic effects of metformin remain elusive. Here, we report that transforming growth factor-beta 1 (TGF-beta 1), which is involved in the pathogenesis of numerous diseases, is a novel target of metformin. Using a surface plasmon resonance-based assay, we identified the direct binding of metformin to TGF-beta 1 and found that metformin inhibits [I-125]-TGF-beta 1 binding to its receptor. Furthermore, based on molecular docking and molecular dynamics simulations, metformin was predicted to interact with TGF-beta 1 at its receptor-binding domain. Single-molecule force spectroscopy revealed that metformin reduces the binding probability but not the binding force of TGF-beta 1 to its type II receptor. Consequently, metformin suppresses type II TGF-beta 1 receptor dimerization upon exposure to TGF-beta 1, which is essential for downstream signal transduction. Thus, our results indicate that metformin is a novel TGF-beta suppressor with therapeutic potential for numerous diseases in which TGF-beta 1 hyperfunction is indicated.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35529
Appears in Collections:分子纳米结构与纳米技术实验室_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100191, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Minist Hlth,Key Lab Mol Cardiovasc Sci,Minist Edu, Beijing 100191, Peoples R China
3.Beijing Key Lab Cardiovasc Receptors Res, Beijing 100191, Peoples R China
4.Chinese Acad Sci, Inst High Energy Phys, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China
5.Chinese Acad Sci, Key Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci, Inst Chem, Beijing 100190, Peoples R China
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Xiao, Han]'s Articles
[Zhang, Jianshu]'s Articles
[Xu, Zhonghe]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Xiao, Han]‘s Articles
[Zhang, Jianshu]‘s Articles
[Xu, Zhonghe]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  中国科学院化学研究所 - Feedback
Powered by CSpace