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题名: Synchronous Detection of Rat Neural Spike Firing and Neurochemical Signals Based on Dual-mode Recording Instrument
作者: Xu Sheng-Wei1, 2; Wang Li1, 2; Song Xian-Teng1, 2; Zhang Song1, 2; Wang Mi-Xia1; Yu Ping2, 3; Mao Lan-Qun2, 3; Cai Xin-Xia1, 2
关键词: Dual-mode ; Neurochemistry ; Spike ; Ascorbic acid ; Microelectrode
刊名: CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
发表日期: 2016-09-01
卷: 44, 期:9, 页:1457-1463
收录类别: SCI
英文摘要: A dual-mode recording system used for synchronous detection of neuroeletrical and neurochemical signals was developed, and a dual-mode synchronous detection experiment was carried out using this instrument. The device comprised a 64-channel neuroelectricity recording module with voltage resolution of 0.3 mu V and a 4-channel neurochemistry recording module with current resolution of 1 pA. The software had many basic detection features as spike separation and sort, chronoamperometry, cyclic voltammetry, etc. In particular, the software could observe and analyze the dual-mode neural signals synchronously. The performance of the system was demonstrated in the single mode detection experiments. In neuroeletrical experiments, 64-channel simulate neural signals were detected and the signal-to-noise ratio (S/N) of spike recorded from cortex of Sprague-Dawley (SD) rat was 6. In the K-3[Fe(CN)(6)] and ascorbic acid measurement experiments, the current response of K-3[Fe(CN)(6)] in the range of 0.1-10 mM was obtained by cyclic voltammetry, with a correlation coefficient of 0.9889, and the current response of ascorbic acid (10-800 mu M) by chronoamperometry increased linearly with a correlation coefficient of 0.9841. Based on the rat model of global cerebral ischemia, a dual-mode detection experiment was carried out. In the experiment, the neuroelectrical and neurochemical signals were synchronously recorded in the SD rat primary visual cortex. According to the experimental results, we got the conclusion that the concentration of ascorbic acid negatively related to the spike firing in the SD rat primary visual cortex.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35479
Appears in Collections:活体分析化学实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Elect, State Key Lab Transducer Technol, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 10090, Peoples R China
3.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Beijing 100190, Peoples R China
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