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题名: Synergistic Coordination and Hydrogen Bonding Interaction Modulate the Emission of Iridium Complex for Highly Sensitive Glutamine Imaging in Live Cells
作者: Jiang, Qin1; Wang, Ming1, 2; Yang, Lifen1; Chen, Hui1, 2; Mao, Lanqun1, 2
刊名: ANALYTICAL CHEMISTRY
发表日期: 2016-10-18
卷: 88, 期:20, 页:10322-10327
收录类别: SCI
英文摘要: Highly selective detection of intracellular glutamine (Gln) is very essential to understand the roles of Gln in some biological processes. Here, we report a new fluorescent method for selective imaging of Gln in live cells with an aldehyde-containing iridium complex, [Ir(pba)(2)(DMSO)(2)]PF6 (Hpba = 4-(2-pyridiyl)benzaldehyde) (Ir1), as the probe. Density functional theory (DFT) calculation and experimental results suggest that the coordination and hydrogen bonding interaction between Ir1 and Gln synergistically stabilize the Ir1-Gln complex, modulate charge-transfer characteristics and emission of Ir1, and as a consequence, enable Ir1 as the probe for the fluorescent sensing of Gln. The sensing strategy is well-responsive to Gln without interference from other amino acids or Gln-containing peptides and is demonstrated to be useful for in situ Gln imaging in live cells. The study provides a new method for fluorescent imaging of Gln in live cells, which is envisioned to find interesting applications in understanding the roles of Gln in some physiological processes.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35466
Appears in Collections:活体分析化学实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, CAS Key Lab Analyt Chem Living Biosyst & Photoche, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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