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题名: A universal strategy for direct immobilization of intact bioactivity-conserved carbohydrates on gold nanoparticles
作者: Wang, Xiao1, 2; Xu, Jiying1; Wang, Yuanyuan1, 2; Wang, Fuyi1, 2; Chen, Yi1, 2, 3
刊名: RSC ADVANCES
发表日期: 2016
卷: 6, 期:88, 页:85333-85339
收录类别: SCI
英文摘要: Carbohydrate-functioned gold nanoparticles have been highlighted for sensing complicated carbohydrates but their performance is far from ideal due to the lack of bioaffinity-conserved ways to function the particles with intact carbohydrates. Herein, we present an innovative method to directly immobilize intact carbohydrates on gold nanoparticles with cyanuric chloride as a linker. Both small and large carbohydrates were successfully immobilized on GNPs at a surface coverage of 43.5% (tested by mannose). Pre-treatment of the carbohydrates was avoided and no loss of their recognition ability towards lectins was observed after immobilization, even in the case of monosaccharides. The mechanism was attributed to the three sigma-linking bonds which are rotatable and spaced at 120 degrees, enabling the immobilized carbohydrates to find their best spatial position to favour their recognition. The method can minimize immobilizing chemical reactions and ease the manipulation by simply controlling the reaction temperature. It is cost-effective and extendable to the immobilization of other hydroxyl compounds and amines as well.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35416
Appears in Collections:活体分析化学实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
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