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题名: Fullerene/photosensitizer nanovesicles as highly efficient and clearable phototheranostics with enhanced tumor accumulation for cancer therapy
作者: Guan, Mirong1; Ge, Jiechao2; Wu, Jingyi1; Zhang, Guoqiang1; Chen, Daiqin1; Zhang, Wei1; Zhang, Ying1; Zou, Toujun1; Zhen, Mingming1; Wang, Chunru1; Chu, Taiwei3; Hao, Xiaojuan4; Shu, Chunying1
关键词: Nanovesicle ; Fullerene ; Photosensitizer ; Phototheranostic
刊名: BIOMATERIALS
发表日期: 2016-10-01
卷: 103, 页:75-85
收录类别: SCI
英文摘要: A novel phototheranostic platform based on tri-malonate derivative of fullerene C-70 (TFC70)/photosensitizer (Chlorin e6, Ce6) nanovesicles (FCNVs) has been developed for effective tumor imaging and treatment. The FCNVs were prepared from amphiphilic TFC70-oligo ethylene glycol -Ce6 molecules. The developed FCNVs possessed the following advantages: (i) high loading efficiency of Ce6 (up to similar to 57 wt%); (ii) efficient absorption in near-infrared light region; (iii) enhanced cellular uptake efficiency of Ce6 in vitro and in vivo; (iv) good biocompatibility and total clearance out from the body. These unique properties suggest that the as-prepared FCNVs could be applied as an ideal theranostic agent for simultaneous imaging and photodynamic therapy of tumor. This finding may provide a good solution to highly efficient phototheranostic applications based on fullerene derivatives fabricated nanostructures. (C) 2016 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35397
Appears in Collections:分子纳米结构与纳米技术实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China
3.Peking Univ, Dept Appl Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
4.CSIRO, Mfg Flagship, Clayton, Vic 3168, Australia
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