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题名: The bridge between thin layer chromatography-mass spectrometry and high-performance liquid chromatography-mass spectrometry: The realization of liquid thin layer chromatography-mass spectrometry (LTLC-MS)
作者: Li, Yafeng1, 2; Wang, Jianing1, 2; Zhan, Lingpeng1, 2; Wleklinski, Michael3, 4; Wang, Jiyun1, 2; Xiong, Caiqiao1, 2; Liu, Huihui1, 2; Zhou, Yueming5; Nie, Zongxiu1, 2, 6
关键词: Interface of MS and TLC ; Ambient ionization ; Pencil mark ; On-line separation and detection ; Reaction monitoring ; Glow discharge ionization
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2016-08-19
卷: 1460, 页:181-189
收录类别: SCI ; ISTP
英文摘要: The combination of thin layer chromatography (TLC) and mass spectrometry (MS) has been studied for decades, but for most cases MS detection is done after TLC separation is finished. Here, an online simultaneous TLC-MS analysis system, liquid thin layer chromatography-mass spectrometry (LTLC-MS), is developed which successfully synchronize TLC separation process and MS detection process like GC-MS and HPLC-MS do. And there's no need to use specially designed TLC, just regular TLC plates are enough. LTLC-MS method is composed of a newly developed ambient ionization method, glow discharge matrix assisted infrared desorption ionization (GD-MAIRDI), and forced-flow TLC (FFTLC) technique, which guarantees the MS detection process does not disturb the TLC separation process throughout the whole analysis. The whole LTLC-MS analysis only need two steps and less than 15 min. Mixtures as well as the two main components of a pain relief pills have been successfully analyzed by LTLC-MS. This proof of concept study opens up new possibilities of combining TLC with MS, and will further broaden the application abilities of TLC. (C) 2016 Elsevier B.V. All rights reserved.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35393
Appears in Collections:活体分析化学实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China
2.Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
3.Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA
4.Purdue Univ, Ctr Analyt Instrumentat Dev, W Lafayette, IN 47907 USA
5.East China Univ Technol, Coll Chem Biol & Mat Sci, Nanchang 330013, Peoples R China
6.Natl Ctr Mass Spectrometry Beijing, Beijing 100190, Peoples R China
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