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题名: Controlled Generation of Singlet Oxygen in Living Cells with Tunable Ratios of the Photochromic Switch in Metal-Organic Frameworks
作者: Park, Jihye1; Jiang, Qin2; Feng, Dawei1; Zhou, Hong-Cai1
关键词: metal-organic frameworks ; nanoparticles ; photochromism ; photodynamic therapy ; singlet oxygen
刊名: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
发表日期: 2016-06-13
卷: 55, 期:25, 页:7188-7193
收录类别: SCI
英文摘要: Development of a photosensitizing system that can reversibly control the generation of singlet oxygen (O-1(2)) is of great interest for photodynamic therapy (PDT). Recently several photosensitizer-photochromic-switch dyads were reported as a potential means of the O-1(2) control in PDT. However, the delivery of such a homogeneous molecular dyad as designed (e.g., optimal molar ratio) is extremely challenging in living systems. Herein we show a Zr-MOF nanoplatform, demonstrating energy transfer-based O-1(2) controlled PDT. Our strategy allows for tuning the ratios between photosensitizer and the switch molecule, enabling maximum control of O-1(2) generation. Meanwhile, the MOF provides proximal placement of the functional entities for efficient intermolecular energy transfer. As a result, the MOF nanoparticle formulation showed enhanced PDT efficacy with superior O-1(2) control compared to that of homogeneous molecular analogues.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35390
Appears in Collections:活体分析化学实验室_期刊论文

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作者单位: 1.Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA
2.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
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