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题名: BSA-Mediated Synthesis of Bismuth Sulfide Nanotheranostic Agents for Tumor Multimodal Imaging and Thermoradiotherapy
作者: Wang, Yong1; Wu, Yongyou2; Liu, Yujing2; Shen, Jia2; Lv, Ling2; Li, Liubing2; Yang, Liecheng3; Zeng, Jianfeng1; Wang, Yangyun3; Zhang, Leshuai W.3; Li, Zhen1; Gao, Mingyuan4; Chai, Zhifang1
刊名: ADVANCED FUNCTIONAL MATERIALS
发表日期: 2016-08-02
卷: 26, 期:29, 页:5335-5344
收录类别: SCI
英文摘要: Fabrication of ultrasmall single-component omnipotent nanotheranostic agents integrated with multimodal imaging and multiple therapeutic functions becomes more and more practically relevant but challenging. In this article, sub 10 nm Bi2S3 biocompatible particles are prepared through a bovine serum albumin (BSA)-mediated biomineralization process under ambient aqueous conditions. Owing to the ultrasmall size and colloidal stability, the resulting nanoparticles (NPs) present outstanding blood circulation behavior and excellent tumor targeting ability. Toward theranostic applications, the biosafety profile is carefully investigated. In addition, photothermal conversion is characterized for both photoacoustic imaging and photothermal treatment of cancers. Upon radiolabeling, the performance of the resulting particles for SPECT/CT imaging in vivo is also carried out. Additionally, different combinations of treatments are applied for evaluating the performance of the as-prepared Bi2S3 NPs in photothermal-and radiotherapy of tumors. Due to the remarkable photothermal conversion efficiency and large X-ray attenuation coefficient, the implanted tumors are completely eradicated through combined therapies, which highlights the potential of BSA-capped Bi2S3 NPs as a novel multifunctional nanotheranostic agent.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35356
Appears in Collections:胶体、界面与化学热力学实验室_期刊论文

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作者单位: 1.Soochow Univ, Collaborat Innovat Ctr Radiat Med, Ctr Mol Imaging & Nucl Med, Jiangsu Higher Educ Inst,Sch Radiol & Interdiscip, Suzhou 215123, Peoples R China
2.Soochow Univ, Affiliated Hosp 2, Suzhou 215004, Peoples R China
3.Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou 215123, Peoples R China
4.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
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