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题名: Biodegradable thermal- and redox-responsive poly(L-glutamate) with Y-shaped oligo(ethylene glycol) side-chain and tunable phase transition temperature
作者: Fu, Xiaohui1, 2; Ma, Yinan2; Sun, Jing2; Li, Zhibo1, 2
刊名: RSC ADVANCES
发表日期: 2016
卷: 6, 期:74, 页:70243-70250
收录类别: SCI
英文摘要: A series of poly(L-glutamate) bearing Y-shaped oligo(ethylene glycol)(x) (OEG(x)) side-chains (PPLG-g-EG(x), x = 2, 3 and 4) were synthesized via a combination of ring opening polymerization (ROP) of gamma-propargyl-L-glutamate N-carboxyanhydride (PLG-NCA) with thiol-yne photoaddition. The solubility of the polypeptides in water was firstly investigated. PPLG-g-EG(3) and PPLG-g-EG(4) were soluble in water and displayed fully reversible thermal-responsive behaviors. Additionally, the polypeptides showed redox-responsive properties along with the conformation associated water solubility due to the presence of thioether groups in the side-chains. In particular, the clouding points (CPs) of the polypeptides are highly tunable depending on the degree of polymerization (DP), the side-chain length, the polymer/salt concentration, and the degree of oxidation/reduction. The key feature of our design is the simultaneous incorporation of thermal-responsive OEG units and redox-responsive thioether linkages by one-step thiol-yne photoaddition, which allows for precisely tuning the phase transition temperature by both stimuli. This synthetic approach offers a facile and efficient way to prepare polypeptide-based biomaterials with highly tunable properties.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35354
Appears in Collections:高分子物理与化学实验室_期刊论文

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作者单位: 1.Qingdao Univ Sci & Technol, Sch Polymer Sci & Engn, Qingdao 266042, Peoples R China
2.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
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