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题名: A Versatile and Clearable Nanocarbon Theranostic Based on Carbon Dots and Gadolinium Metallofullerene Nanocrystals
作者: Guan, Mirong1, 2; Li, Jie1, 2; Jia, Qingyan3; Ge, Jiechao3; Chen, Daiqin1, 2; Zhou, Yue1, 2; Wang, Pengfei3; Zou, Toujun1, 2; Zhen, Mingming1, 2; Wang, Chunru1, 2; Shu, Chunying1, 2
关键词: clearance ; imaging ; nanocarbon ; photodynamic therapy ; theranostics
刊名: ADVANCED HEALTHCARE MATERIALS
发表日期: 2016-09-07
卷: 5, 期:17, 页:2283-2294
收录类别: SCI
英文摘要: Nanocarbons such as carbon nanotubes, graphene derivatives, and carbon nanohorns have illustrated their potential uses as cancer theranostics owing to their intrinsic fluorescence or NIR absorbance as well as superior cargo loading capacity. However, some problems still need to be addressed, such as the fates and long-term toxicology of different nanocarbons in vivo and the improvement of their performance in various biomedical imaging-guided cancer therapy systems. Herein, a versatile and clearable nanocarbon theranostic based on carbon dots (CDs) and gadolinium metallofullerene nanocrystals (GFNCs) is first developed, in which GFNCs enhance the tumor accumulation of CDs, and CDs enhance the relaxivity of GFNCs, leading to an efficient multimodal imaging-guided photodynamic therapy in vivo without obvious long-term toxicity. Furthermore, biochemical analysis reveals that the novel nanotheranostic can harmlessly eliminate from the body in a reasonable period of time after exerting diagnostic and therapeutic function.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35312
Appears in Collections:分子纳米结构与纳米技术实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100190, Peoples R China
2.Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Key Lab Photochem Convers & Optoelect Mat, TIPC, Beijing 100190, Peoples R China
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