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题名: Hierarchical Structures of Bone and Bioinspired Bone Tissue Engineering
作者: Liu, Yan1; Luo, Dan2, 3; Wang, Tie2
刊名: SMALL
发表日期: 2016-09-14
卷: 12, 期:34, 页:4611-4632
收录类别: SCI
英文摘要: Bone, as a mineralized composite of inorganic (mostly carbonated hydroxyapatite) and organic (mainly type I collagen) phases, possesses a unique combination of remarkable strength and toughness. Its excellent mechanical properties are related to its hierarchical structures and precise organization of the inorganic and organic phases at the nanoscale: Nanometersized hydroxyapatite crystals periodically deposit within the gap zones of collagen fibrils during bone biomineralization process. This hierarchical arrangement produces nanomechanical heterogeneities, which enable a mechanism for high energy dissipation and resistance to fracture. The excellent mechanical properties integrated with the hierarchical nanostructure of bone have inspired chemists and material scientists to develop biomimetic strategies for artificial bone grafts in tissue engineering (TE). This critical review provides a broad overview of the current mechanisms involved in bone biomineralization, and the relationship between bone hierarchical structures and the deformation mechanism. Our goal in this review is to inspire the application of these principles toward bone TE.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35292
Appears in Collections:活体分析化学实验室_期刊论文

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作者单位: 1.Peking Univ Sch & Hosp Stomatol, Dept Orthodont, Ctr Craniofacial Stem Cell Res & Regenerat, Beijing 100081, Peoples R China
2.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
3.China Univ Petr, Inst New Energy, State Key Lab Heavy Oil Proc, Beijing 102249, Peoples R China
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