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题名: Biomimetic membrane-conjugated graphene nanoarchitecture for light-manipulating combined cancer treatment in vitro
作者: Qin, Chenchen; Fei, Jinbo; Cai, Peng; Zhao, Jie; Li, Junbai1
关键词: Biomimetic membrane ; Graphene oxide ; Drug delivery ; Cancer therapy
刊名: JOURNAL OF COLLOID AND INTERFACE SCIENCE
发表日期: 2016-11-15
卷: 482, 页:121-130
收录类别: SCI
英文摘要: We report that through facile lipid self-assembly, biomimetic membrane-conjugated mesoporous silica coated graphene oxide is constructed as targeting nanocarrier toward efficient combination of photothermal therapy and chemotherapy. Impressively, the simple surface modification with folate-contained lipid bilayer allows the graphene-based nanoarchitecture above to be selectively internalized by tumor cells overexpressing relevant receptors. Compared to pure drug, 7-fold doxorubicin is delivered into tumor cells by the nanoarchitecture. After cellular internalization, upon near infrared light illumination, graphene oxide in the nanoarchitecture can convert light energy into heat to kill cancer cells partially. Simultaneously, hyperthermia will drive rapid release of doxorubicin from the nanoarchitecture above to further cause the death of more cancer cells. Thus, integrated cancer treatment with higher efficacy is achieved in vitro compared to that of individual therapy. (C) 2016 Elsevier Inc. All rights reserved.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35270
Appears in Collections:胶体、界面与化学热力学实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing Natl Lab Mol Sci, North First St 2, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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