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题名: Extremely Stable Supramolecular Hydrogels Assembled from Nonionic Peptide Amphiphiles
作者: Wan, Yaoming1; Wang, Zuoning1; Sun, Jing2; Li, Zhibo1, 2
刊名: LANGMUIR
发表日期: 2016-08-02
卷: 32, 期:30, 页:7512-7518
收录类别: SCI
英文摘要: Peptide hydrogels with high stability in different media are of great interest in biomedical applications. In this paper, we report an easy, fast, and scalable method for preparing a family of nonionic peptide amphiphiles (PAs) obtained by direct aminolysis of alkyl-oilgo(gamma-benzyl-L-glutamate) samples, which were synthesized via the alkyl amine-initiated sequence ring-opening reaction of alpha-amino acid N-carboxyanhydrides. One great advantage of this method is that vast chemical diversity and large-scale yields can be achieved easily using commercially available hydramines. These PA samples can readily form a clear hydrogel without any external aid and show exceptionally enhanced gelation properties with a critical gelation concentration as low as 0.05 wt %. The hydrogels are highly stable against extreme pH values of 1 and 14 and a high salt concentration of 200 mM NaCl. These properties combined with the shear-thinning properties make these PA hydrogels ideal candidates for the new generation of injectable scaffolds.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35264
Appears in Collections:高分子物理与化学实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci BNLMS, Beijing 100190, Peoples R China
2.Qingdao Univ Sci & Technol, Sch Polymer Sci & Engn, Qingdao 266042, Peoples R China
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