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题名: Bio-inspired Dynamic Gradients Regulated by Supramolecular Bindings in Receptor-Embedded Hydrogel Matrices
作者: Luan, Xinglong1; Zhang, Yihe1; Wu, Jing2; Jonkheijm, Pascal3; Li, Guangtao4; Jiang, Lei5; Huskens, Jurriaan3; An, Qi1
关键词: cyclodextrin ; diffusion ; dynamic gradients ; hydrogels ; supramolecular binding
刊名: CHEMISTRYOPEN
发表日期: 2016-08-01
卷: 5, 期:4, 页:331-338
收录类别: SCI
英文摘要: The kinetics of supramolecular bindings are fundamentally important for molecular motions and spatial-temporal distributions in biological systems, but have rarely been employed in preparing artificial materials. This report proposes a bio-inspired concept to regulate dynamic gradients through the coupled supramolecular binding and diffusion process in receptor-embedded hydrogel matrices. A new type of hydrogel that uses cyclodextrin (CD) as both the gelling moiety and the receptors is prepared as the diffusion matrices. The diffusible guest, 4-aminoazobenzene, quickly and reversibly binds to matrices-bound CD during diffusion and generates steeper gradients than regular diffusion. Weakened bindings induced through UV irradiation extend the gradients. Combined with numerical simulation, these results indicate that the coupled binding-diffusion could be viewed as slowed diffusion, regulated jointly by the binding constant and the equilibrium receptor concentrations, and gradients within a bio-relevant extent of 4mm are preserved up to 90h. This report should inspire design strategies of biomedical or cell-culturing materials.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35258
Appears in Collections:有机固体实验室_期刊论文

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作者单位: 1.China Univ Geosci, Beijing Key Lab Mat Utilizat Nonmetall Minerals &, Natl Lab Mineral Mat, Sch Mat Sci & Technol, Beijing 100083, Peoples R China
2.China Univ Geosci, Sch Sci, Beijing 100083, Peoples R China
3.Univ Twente, Mol Nanofabricat Grp, MESA Inst Nanotechnol, NL-7500 AE Enschede, Netherlands
4.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
5.Chinese Acad Sci, Inst Chem, Beijing 100084, Peoples R China
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