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题名: New Tanshinone IIA Delivery System Using Chitosan Nanomicelles of Small Size
作者: Li Hong1, 3; Du Libo1; Zhang Han1; Zhao Yuming2; Liu Yang1, 3
关键词: Chitosan nanomicelles of small size ; Tanshinone IIA ; Neuroprotectant ; Delivery for poorly soluble drugs
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2016-07-10
卷: 37, 期:7, 页:1229-1231
收录类别: SCI
英文摘要: It is still a great challenge to design and synthesize ultra. small chitosan nanoparticles for encapsulating highly hydrophobic neuroprotectants, such as anti. stroke drug tanshinone IIA. To address the issue, a new amphiphilic polymeric micelle system (i.e. CS-g-TPS) was synthesized by covalent linking of D-alpha-tocopherol succinic acid ester with hydroxylethyl. chitosan in a green and effective approach. The results showed that the obtained CS-g-TPS can be self. assembled into ultra. small nanoparticles by hydrophilic. hydrophobic interaction in aqueous solution, which can be effectively loaded with tanshinone IIA. The particle size and morphology were characterized by scanning electron microscopy(SEM) and dynamic light scattering (DLS), respectively. Bioassays of cell viability and drug uptake further revealed that the CS-g-TPS/tanshinone IIA delivery system could achieve excellent in vitro biocompatibility, as well as high cellular uptake efficiency. It indicated that CS-g-TPS might be a promising drug delivery system for water insoluble neuroprotectant with the characteristics of high biosafety.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35192
Appears in Collections:分子动态与稳态结构实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
2.Capital Med Univ, Sch Basic Med Sci, Beijing 100069, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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