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题名: A New Tetraphenylethylene-Derived Fluorescent Probe for Nitroreductase Detection and Hypoxic-Tumor-Cell Imaging
作者: You, Xue1, 2; Li, Lihong1, 2; Li, Xiaohua1; Ma, Huimin1, 2; Zhang, Guanxin1; Zhang, Deqing1, 2
关键词: aggregation ; fluorescence ; imaging agents ; nitroreductase ; tetraphenylethylene
刊名: CHEMISTRY-AN ASIAN JOURNAL
发表日期: 2016-10-01
卷: 11, 期:20, 页:2918-2923
收录类别: SCI
英文摘要: The fluorescence detection of nitroreductase ( NTR) and evaluation of the hypoxia status of tumor cells are vital, not only for clinical diagnoses and therapy, but also for biomedical research. Herein, we report the synthesis and application of a new fluorometric "turn-on" probe for the detection of NTR ( TPE-NO2) that takes advantage of the aggregation-induced emission of tetraphenylethylene. TPE-NO2 can detect NTR at concentrations as low as 5 ng mL(-1) in aqueous solution. The detection mechanism relied on the aggregation and deaggregation of tetraphenylethylene molecules. Moreover, this fluorescent probe can be used to monitor the hypoxia status of tumor cells through the detection of endogenous NTR.
语种: 英语
内容类型: 期刊论文
URI标识: http://ir.iccas.ac.cn/handle/121111/35113
Appears in Collections:活体分析化学实验室_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Labs Organ Solids & Analyt Chem Living Biosyst, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
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